Professor of Cell Biology
Centre for Molecular and Metabolic Signalling
Division of Basic Medical Sciences
St. George's, University of London
Prof Bennett was educated at King’s College, Cambridge, UK and did her PhD in the group of Renato Dulbecco (Nobel Prize, 1975) at the Imperial Cancer Research Fund Laboratories, London, UK (now CR-UK London Research Institute). From 1979, she did postdoctoral fellowships with Prof Dulbecco, now at the Salk Institute, La Jolla, California, and with James A Smith back at the ICRF Laboratories, London. She moved to St George’s as a full-time independent researcher in 1983, and has worked there since then, in academic positions from lecturer (assistant professor) to her current role of Professor (personal chair) of Cell Biology.
Her research has always involved cell culture and cell biology. Its focus began with from breast cancer and its stem cells, and moved to studies of cell differentiation in relation to the cell cycle and malignancy, in melanoma cells. Her group currently works on functional genetic analysis of pigmentation and pigmentary disorders including vitiligo and melanoma, in collaboration with a number of other research groups around the world. One speciality is the establishment of normal and differentiated mammalian cells in culture, especially melanocytes carrying various pigmentary mutations. The group manages the Wellcome Trust Functional Genomics Cell Bank, dedicated to providing these cultures to researchers in all countries.
Prof Bennett is a member of a number of scientific societies, and of various national and international scientific and medical advisory committees and panels. She has received two international research awards. She is Past President of the ESPCR – European Society for Pigment Cell Research, and of the IFPCS – International Federation of Pigment Cell Societies, the bridging organization for scientific societies in this field.
Developmental Genetics of Melanocytes
UMR146 CNRS, Institut Curie
Bat 110, Centre universitaire
91405 Orsay Cedex
France
A. POSITIONS
• Graduate student, University of Paris VI. Thesis in Unité de Pharmacologie-Moléculaire, 1982-1988
laboratory of Drs Le Pecq – Paoletti, Institut Gustave-Roussy, Villejuif, France
- Accessibility of antitumor drugs to in vitro and in vivo DNA
• Postdoctoral Associate, Fox Chase Cancer Center, Philadelphia, PA, laboratory of Dr. B. Mintz 1988-1991
- Determination, Differentiation, and Transformation of Melanocytes
- Establishment of a melanoma murine system using transgenesis (mice and cell lines)
• Research Associate, Max-Planck Institut für Immunbiologie, Freiburg, Germany, 1991-1995
laboratory of Dr. R. Kemler
- Cadherins as morphoregulators
• Chargé de Recherche in the department UMR144 CNRS, Curie Institute, Orsay, France 1995-1996
• Chargé de Recherche, Group leader in the department UMR146 CNRS, Curie Institute, Orsay 1997-2003
- Developmental Genetics of Melanocytes
• Directeur de Recherche, Group leader in the department UMR146 CNRS, Curie Institute Orsay 2003-date
- Developmental Genetics of Melanocytes
HONORS
• ARC fellowship (Villejuif, France) 1987-1988
• NIH/Fox Chase Cancer Center Fellowship 1988-1991
• Human Frontier Science Program Fellowship 1992-1994
B. PEER-REVIEWED PUBLICATIONS (2003-2007) – Lionel Larue, Ph.D.
• Julien, S., Puig, I., Caretti, E., Bonaventure, J., Nelles, L., van Roy, F., Dargemont, C., Garcia de Herreros, A., Bellacosa, A. and Larue L. Activation of NF-?B by Akt upregulates Snail expression and induces epithelium mesenchyme transition. accepted Oncogene.
• Javelaud D., Mohammad K.S., McKenna C.R., Fournier P., Luciani F., Niewolna M., André J., Delmas V., Larue L., Guise T.A., and Mauviel A. Stable Overexpression of Smad7 in Human Melanoma Cells Inhibits Bone Metastasis.Cancer Research. In Press.
• Schouwey, K., Delmas, V., Larue L., Zimber-Strobl U., Strobl L.J., Radtke F. and Beermann F. (2007) Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev. Dyn. 236(1):282-9. PMID: 17080428
• Carreira S, Goodall, J, Denat, L, Rodriguez, M, Nuciforo, P, Hoek, KS. Testori, A, Larue L and Goding, CR. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes & Dev. (2006) 20, 3426-3439 PMID: 17182868.
• Hamaï, A., Richon, C., Meslin, F., Faure, F., Kauffmann, A., Lecluse, Y., Jalil, A., Larue, L., Avril, M.F., Chouaib S. and Mehrpour, M. Imatinib enhances human melanoma cells susceptibility to TRAIL-induced cell death. Oncogene (2006) 25, 7618-7634 PMID: 16983347
• Moriyama, M., Osawa, M., Mak, SS, Ohtsuka, T. Yamamoto, N., Han, H. Delmas, V. Kageyama, R., Beermann, F., Larue, L. and Nishikawa SI. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J. Cell Biol. (2006). 173 :333-9. PMID: 16651378
• Yajima, I., Belloir, E., Bourgeois, Y., Kumasaka, M., Delmas, V. and Larue, L. Spatio-temporal gene control by the Cre-ERT2 system in melanocytes. Genesis (2006). 44 : 34-43. PMID: 16419042
• Dasgupta, A., Hughey, R., Lancin, P., Larue, L., and Moghe P.V. E-Cadherin Expression Induces Hepatospecific Phenotype and Maturation in Murine Embryonic Stem Cells Biotechnology and Bioengineering (2005). 92 : 257-266. PMID: 16167333
• Javelaud, D., Delmas, V., Moeller, M., Sextius, P., Menashi, S., Larue, L., and Mauviel, A. Stable overexpression of Smad7 in human melanoma cells inhibits theirtumorigenicity in vitro and in vivo. Oncogene (2005). 24 : 7624-7629. PMID: 16007121
• Pla , P., Alberti, C., Solov'eva, O., Kunisada, T. and Larue, L. Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation. Pigment Cell R. (2005) 18 :181-187. PMID: 15892714
• Carreira, S., Goodall, J, Isil Aksan, I., Anna La Rocca, S., Galibert, M.D., Denat, L., Larue, L., and Goding C.R. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature (2005), 433 :764-769. PMID: 15716956
• Barbera MJ, Puig I, Dominguez D, Julien-Grille S, Guaita-Esteruelas S, Peiro S, Baulida J, Franci C, Dedhar S, Larue L, and Garcia de Herreros A. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. (2004), 23:7345-54. PMID: 15286702
• Pla, P., Solov’eva, O., Moore, R., Alberti, C., Kunisada, T. and Larue, L. Dct::lacZ ES cells: A novel cellular model to study melanocyte determination and differentiation. Pigment Cell R. (2004), 17, 142-149. This article got an award of excellence in 2004. PMID: 15016303
• Montoliu, L., Larue, L. and Beermann, F. On the use of regulatory regions from pigmentary genes to drive the expression of transgenes in mice. Pigment Cell R. (2004) 17: 188-190. PMID: 15016310
• Goodall, J., Martinozzi, S., Dexter, T.J., Champeval, D., Carreira, S., Larue, L. and Goding C.R. The Brn-2 promoter is a direct target for activation by b-catenin. Mol Cell. Biol., (2004) 24: 2915-22. (voir communiqué de presse et articles de presse). PMID: 15024079
• Moore, R., Champeval, D., Denat, L., Tan, SS, Faure, F. Julien-Grille, S. and Larue L. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. Oncogene, (2004) 23:6726-35. PMID: 15273735
• Julien-Grille, S., Bellacosa, A., Upson, J., Klein-Szanto, AJ., van Roy, F., Donowitz, M., Tsichlis, PN., and Larue, L. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Research. (2003), 63, 2172-2178. (Communiqué de presse et articles de presse). PMID: 12727836
• Delmas, V., Martinozzi, S., Bourgeois, Y., Holzenberger, M., and Larue, L. Cre-mediated recombination in the skin melanocyte lineage. Genesis. (2003), 36, 73-80. PMID: 12820167
• Biet, E., Alberti, C., Faccella, P., Sun, JS, Dutreix, M., and, Larue, L. Tyrosinase gene correction using fluorescent oligonucleotides. Pigment Cell R. (2003), 16, 133-138. See commentary in Pigment Cell Res. (2003), 16, 89. PMID: 12622790
• Cortellino, S., Turner, D., Masciullo, V., Schepis, F., Albino, D., Daniel, R., Skalka, A.M., Meropol, N.J., Alberti, C. Larue, L., and Bellacosa, A. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc. Natl. Acad. Sci. (USA). (2003), 100, 15071-6. PMID: 14614141
C. REVIEW ARTICLES – (2003-2007) – Lionel Larue, Ph.D.
• Denat L. et Larue L. (2007) Le mélanome malin cutané et le rôle de la protéine paradoxale Microphthalmia Transcription Factor. Bulletin du Cancer. 94 :81-92.
• Larue L. and Delmas, V. (2006) The Wnt/beta-?catenin pathway in melanoma. Frontiers in Biosciences. 11 :733-42. PMID: 16146765
Associate Professor of Pathology
Loyola University Medical Center
Bldg 112, Rm 203/ Lab 210
2160 S. 1st Avenue
Maywood, IL 60153
USA
Dr. Le Poole studied Biology (Majors: Microbiology, Molecular Cell Biology and Bioprocess Technology) at Utrecht University in the Netherlands (M.S., 1987) and went on to receive a Ph.D. in Medicine from the Department of Dermatology at Amsterdam University, also in the Netherlands on ‘Aspects of Melanocytes in Relation to Vitiligo’ (Ph.D., 1993). She was the first woman ever to receive a Ph.D. from this century old Department. Dr Le Poole completed further postdoctoral studies on melanocyte adhesion in Amsterdam until 1995. After a short sabbatical at the CNRS in Orleans, France she obtained a Stipend from the Dutch Organization for Pure Scientific Research (NWO), and came to the University of Cincinnati (OH) in 1995 to characterize differential gene expression in vitiligo melanocytes in the laboratory of Dr. Raymond Boissy. The first vitiligo-associated gene VIT1 was identified and Dr Le Poole received a Young Investigator Award from the Pan American Society for Pigment Cell Research for these studies. In Cincinnati, Dr. Le Poole also worked with Dr. Steven Boyce on cytokine expression in reconstituted skin at the Shriners Burns Institute. In 1998, Dr. Le Poole was appointed as Research Assistant Professor of Dermatology and obtained a Career Development Award from the Dermatology Foundation to investigate the autoimmune response in vitiligo. In 1999, she moved to Chicago to join Dr. Nickoloff’s Cutaneous Oncology program as a (Research) Assistant Professor of Pathology at Loyola University Medical Center.
Autoimmune recognition of melanocytes in vitiligo remains a primary research interest of Dr. Le Poole, as well as dendritic cell effector functions and immune recognition of tumor cells. The progressive loss of skin color as observed in vitiligo is considered a positive prognostic factor in patients with malignant melanoma, where the immune response all to often fails to clear patients of their tumor. By studying effective recognition of melanocytic cells in vitiligo, Dr. Le Poole aims to contribute to the development of new anti-melanoma vaccines.
Dr. Le Poole has authored 50 book chapters and publications in peer reviewed scientific journals. She was elected secretary of the Chicago Association of Immunologists (2000-2002), and her current activities include the Directorship of the Immune Monitoring Core in the Cardinal Bernardin Cancer Center, where patient immune responses to experimental vaccines are characterized and quantified.
Prof. Torello Lotti
Ordinario di Dermatologia
Direttore U.O. Dermatologia Complessa
Direttore Scuola di Specializzazione in Dermatologia e Venereologia
Università di Firenze
Professore Ordinario di Dermatologia
e Direttore U.O.Complessa Dermatologica di Fisioterapia Dermatologica
(Full Professor of Dermatology and Chairman University Unit of Dermatology
and Physiotherapy)
Dipartimento di Scienze Dermatologiche
Università degli Studi di Firenze,
Facoltà di Medicina e Chirurgia.
Visiting Professor & Director, International Centre for Balneology, Cell Biology,
and Physiotherapy Thomas Jefferson University, Philadelphia (PA, USA)
Visiting Professor of Dermatology, Charles University, Prague, republica Ceca
Visiting Professor of Dermatology, Bowman Gray University, Winston Salem (NC, USA)
Visiting Professor of Dermatology, University of Louisville, Louisville (KY, USA)
Visiting Professor of Dermatology, Medical University of South Carolina, Charleston (SC,USA)
Visiting Professor of Dermatology, Charles University, Prague, Czech Republic
University Medal, Charles University, Czech Republic
Key Note Lecturer, Japanese Society of Cosmetic Dermatology
Chairman Centro Universitario di Dermatologia Biologica e Psicosomatica,
Università di Firenze, Siena e Milano, Italy.
LUOGO E DATA DI NASCITA: 23 aPRILE, 1953 - Pieve a Nievole (PT), Italy
STATO CIVILE: Sposato, due figli
STUDI UNIVERSITARI:
1972-78 Università di Firenze, Corso di Laurea in Medicina e Chirurgia
1978 Laurea in Medicina e Chirurgia (cum laude)
1981 Specializzazione in Dermatologia, (cum laude)
FORMAZIONE POST-LAUREA:
1978-81 Specializzazione in Dermatologia e Venereologia, Università di Firenze
1983-84 Medico Residente presso l’Istituto di Dermatologia, Londra, UK
ESPERIENZE PROFESSIONALI:
1981-83 Medico Frequentatore Università di Firenze
1983-91 Assistente Ospedaliero presso l’Istituto di Clinica Dermosifilopatica dell’ Università di Firenze
1986-91 Professore a Contratto di Semeiotica Dermatologica presso l’Università di Firenze
1991-97 Professore Associato di Dermatologia e Responsabile della Cattedra di Dermatologia e Venereologia al Corso di Laurea di Odontoiatria, Univerità di Siena
1994- Visiting Professor of Dermatology, Thomas Jefferson University, Philadelphia (PA, USA).
1995- Visiting Professor of Dermatology, Bowman Gray University, Winston Salem (NC, USA)
1996- Visiting Professor of Dermatology, University of Louisville, Louisville (KY, USA)
1997- Professore Associato di Dermatologia e Venereologia, presso l’Istituto di Clinica Dermosifilopatica dell’ Università di Firenze
1999- Visiting Professor of Dermatology, Medical University of South Carolina (Charlestone,SC,USA)
1999- Responsabile Servizi Assistenziali di Dermatologia, Policlinico Universitario di Careggi (Firenze)
1999 Responsabile del Modulo Operativo di Fisiopatologia Dermatologica, Università di Firenze
2001 Direttore UO di Dermatologia Allergologica, Professionale e Ambientale, Università di Firenze
2002 Visiting Professor of Dermatology, Charles University, Prague, Republica Ceca
2003 University Medal, Charles University, Czech Republic Key Note Lecturer, Japanese Society of Cosmetic Dermatology
Chairman Centro Universitario di Dermatologia Biologica e Psicosomatica, Università di Firenze, Siena e Milano, Italy.
TEACHING APPOINTMENTS:
- Dermatology (medical students, Florence, Italy)
- Dermatology (post graduate, residents, Florence, Italy)
- Tutor in Dermatology (post graduate, residents, Florence, Italy)
- Associate Professor of Dermatol. (students, post post graduate, residents, Siena, Italy)
- professor Centro Interuniversitario di Dermatologia Biologica e Psicosomatica (Università di Firenze, Milano e Siena, Italy)
- Visiting of Dermatology (Philadelphia, USA)
- Visiting Professor of Dermatology, Bowan Gray University (Winston Salem, USA)
- Visiting Professor of Dermatology, University of Louisville, Louisville (KY, USA)
- Visiting Professor of Dermatology, Medical University of South Carolina, Charlston (SC, USA)
Dipartimento di Scienze Dermatologiche
Università di Firenze
via della Pergola 60
50121 Firenze, Italy
Prof.ssa Silvia Moretti – Professore Associato in Dermatologia, Dipartimento di Scienze Dermatologiche, Università di Firenze
La Prof.ssa Silvia Moretti, nata a Firenze il 29/02/1952, si è laureata in Medicina e Chirurgia cum Laude nel 1976 presso l’Università di Firenze. Qui si è poi specializzata in Endocrinologia nel 1979 e in Dermatologia e Venereologia nel 1982, entrambi cum Laude. Borsista dal 1976, poi Tecnico Laureato e quindi Coordinatore Tecnico presso l’Istituto di Clinica Dermosifilopatica dell’Università di Firenze, è Dirigente Medico di I Livello dal 1997 presso la U.O. di Dermatologia II del Dipartimento di Scienze Dermatologiche dell’Università di Firenze e dal 2004 Professore Associato presso lo stesso Dipartimento.
Nell’ambito della pratica clinica si occupa in modo particolare di dermatologia oncologica, disordini della pigmentazione (è responsabile dell’ambulatorio di dermatologia oncologia e disordini della funzionalità melanocitaria e delle terapie mediche dei pazienti oncologici o affetti da vitiligine nell’ambito della U.O di Dermatologia II), e patologie cutanee immuno-mediate.
Referente del EORTC-MCG (European Organization for Research and Treatment of Cancer- Melanoma Cooperative Group) per il Dipartimento di Scienze Dermatologiche dell’Università di Firenze, è referente oncologico della II Clinica Dermatologica dell’Università di Firenze per l’Azienda Sanitaria di Firenze e membro designato della II Clinica Dermatologica nel gruppo di studio “Tumori della cute” nell’ambito della Azienda Sanitaria di Firenze.
E’ docente di Dermatologia nel corso di Laurea in Medicina e Chirurgia, nei corsi di Laurea in Infermieristica e in Assistenza Sanitaria e nella scuola di specializzazione in Dermatologia e Venereologia della Facoltà di Medicina e Chirurgia dell’Università di Firenze; è chiamata in qualità di docente a corsi, seminari e masters organizzati da Università o Regione Toscana.
E’ autrice di oltre 100 pubblicazioni in estenso su riviste indexate, di oltre 200 presentazioni a congressi nazionali e internazionali, e di 22 capitolidi libri, riguardanti prevalentemente la dermatologia oncologica, le patologie cutanee immuno-mediate e i disordini della pigmentazione.
Ha studiato le malattie linfoproliferative con interessamento cutaneo (contribuendo alla precisazione del fenotipo delle cellule infiltranti la cute e dei loro rapporti con il microambiente cutaneo, nonché alla identificazione di appropriate terapie), le lesioni melanocitiche, (studiando i fattori biologici correlati alla progressione tumorale del melanoma, l’attività angiogenetica e l’interazione delle cellule neoplastiche con il microambiente circostante, la terapia delle forme avanzate di melanoma), la vitiligine (evidenziando nuove alterazioni nel microambiente epidermico), e le alopecie cicatriziali (con particolare riguardo alle modalità patogenetiche della evoluzione fibrotica).
Ha trascorso soggiorni di studio in Olanda e negli Stati Uniti. Ha stretto collaborazioni di ricerca con vari Istituti dell’Università di Firenze e di altre Università italiane e straniere. E’ membro delle seguenti società scientifiche: Società Italiana di Dermatologia (SIDeMaST), European Society for Dermatological Research (ESDR), European Acade¬my of Dermatology and Venereology (EADV), European Society for Pigment Cell Research (ESPCR), European Organization for Research and Treatment of Cancer melanoma Cooperative Group (EORTC-MCG). E’ revisore delle seguenti riviste internazionali: Journal of European Academy of Dermatology and Venereology, Journal of Haematology and Oncology, Medical Science Monitor, Pigment Cell Research, Dermatology, Melanoma Research, Neuropeptides.
Fa parte del comitato fondatore del Vitiligo European Task Force (VETF), gruppo europeo volto alla identificazione di linee guida classificative, terapeutiche e di ricerca nella vitiligine, e del Gruppo Italiano di Ricerca Sperimentale in Dermatologia (GIRSDE), nell’ambito della SIDeMaST.
Direttore Laboratorio di Genetica Medica
Azienda Ospedaliera Policlinico Tor Vergata
Viale Oxford 1
00133 Roma (Italy)
CURRENT POSITION
Full Professor of Human Genetics Tor Vergata University of Rome, School of Medicine And Adjunct Professor, Division of Cardiology, University of Arkansas, Little Rock, (USA)
EDUCATION
1981 BS Biology, Urbino University
1985 PhD Medical Genetics, University of Rome La Sapienza
PROFESSIONAL BACKGROUND
1981-1983 Assistant Researcher Urbino University
1983-1992 Assistant Professor Urbino University
1983-1984 Visiting Researcher Unite’ de Recherches de Biologie Prenatale
INSERM U 73, Paris (France)
1990-1990 Groupe de Gènètique Molèculaire INSERM U.91 Creteil (France).
1992-1995 Associate Professor Catholic University of Rome
1996 Visiting Professor University of Southern California (Los Angeles),
Department of Biochemistry and Molecular Biology;
1995-1999 Associate Professor Tor Vergata University of Rome
2001 Director of Medical Genetics Laboratory at The Tor Vergata Hospital
2002 Professor of Medical Genetics Faculty of Science University of Urbino
MEMBERSHIP IN SCIENTIFIC SOCIETIES
Member of the Editorial Board of: Neuromuscular Disorders (1999-2003); Clinical Genetics
(pending); Acta Myologica (pending); Expert Opinion on Pharmacotherapy (pending); BMC
Medical Genetics
Membership: American Society of Human Genetics (USA); European Society of Human
Genetics (ESHG); American Association for the Advancement of Science (USA); Human
Genome Organization (HUGO); Italian Society of Human Genetics (SIGU); World Muscle
Society (WMS); American Society of Physiology; American Society of Gene Therapy
PUBLICATIONS
Author of 280 scientific publications appeared on International and Peer reviewed Journals.
Author and co-author of 4 books on Medical Genetics
Inventor and co-inventor of 3 Patents regarding antibodies and molecular protocols.
SCIENTIFIC INTERESTS
Genomic analysis of significant public health problems,
Genomic analyses of humankind,
Gene/environment interactions,
Functional analysis of SNPs (single nucleotide polymorphisms),
Molecular Genetics of rare diseases
Professore di Dermatologia
all’Università di Nizza, (Francia)
Chairman del Dipartimento di Dermatologia .
Prof. Jean-Paul Ortonne
University Professor of Dermatology at the University of Nice-Sophia Antipolis, Chairman of the Department of Dermatology and Head of the INSERM U385 Research Unit "Biology and Pathophysiology of the Skin".
Founding Member and Past-president of the French Society for Dermatological Research.
Past president and member of the Board of the French Society of Dermatology and Venerology.
Past president of the European Society of Dermatology and Venerology.
General Secretary of the World Congress of Dermatology 2002.
Editor of "Journal of the European Academy of Dermatology and Venerology".
Department of Medical Sciences
Section of Dermatology & Venereology
University Hospital
SE-751 85 Uppsala
SVEZIA
Dr. Mats J. Olsson is an internationally well recognised vitiligo specialist. Dr. Olsson is the head of the vitiligo research group at the department of Medical Sciences, section of Dermatology at Uppsala University, Sweden and is also running the surgical treatment unit at the University Hospital Dermatology Clinic. Dr. Olsson has also been active in vitiligo research at Yale University.
Dr. Olsson is one of the few who has written a doctoral thesis specifically on vitiligo. The title of the book is Vitiligo and Piebaldism, “Treatment of Leucoderma by Transplantation of autologous melanocytes” (ISBN 91-554-5080-6) and has since then been the lead scientist is many pre-clinical and clinical vitiligo research projects which has resulted in numerous international scientific publication.
Dr. Olsson has developed defined culture systems for human pigment cells and three different surgical procedures for restoring the pigment loss in the white patches. The methods are today well established and in practical use at several institutes around the world. Dr. Olsson have been in charge of establishing new research technologies, laboratories and specialised dermatological clinics in several countries, both in academia and private sector.
Dr. Olsson is also one of the authors and editor of the book Surgical Management of Vitiligo, Published by Blackwell Publishing (ISBN 1-4051-4521-8).
Responsabile Laboratorio di Fisiopatologia Cutanea Istituto Dermatologico San Gallicano IRCCS - Roma
E' nato a Caltanissetta il 3/12/1954. Coniugato con due figli.
Presso l'Università "La Sapienza" di Roma si è laureato nel 1978 in Medicina e Chirurgia, si è specializzato nel 1981 in Allergologia ed Immunologia Clinica e nel 1984 in Dermatologia e Venereologia.
Nel 1981 è diventato aiuto presso il Laboratorio di Istofisiopatologia dell¹Istituto San Gallicano e dal 1996 dirige lo stesso Laboratorio.
Dall'Aprile 1998 al 2000 ha ricoperto la funzione di collaboratore del Direttore Scientifico dell'Istituto San Gallicano e da dicembre 2000 al 3 agosto 2006 è stato Direttore Scientifico dell'Istituto San Gallicano.
Fa parte di numerose Società Scientifiche italiane e internazionali (Società Italiana di Dermatologia e Venereologia, European Society for Dermatological Research, European Accademy of Allergology and Clinical Immunology, European Dermatological Forum; è componente del Board della European Immunodermatology Society, della European Society for Pigment Cell Research).
E¹ componente del "Editorial Board"; o referee di diverse riviste scientifiche (Pigment Cell Research Bulletin, Experimental Dermatology, Clinical and Experimental Dermatology). L¹attività di ricerca ha riguardato i meccanismi della pigmentazione cutanea e delle patologie connesse, la biochimica della formazione della melanina e dell'azione di diversi inibitori della melanogenesi, le alterazioni della sintesi della melanina nelle malattie depigmentarie e nelle patologie neoplastiche dei melanociti in modelli animali e in vitro.
Ha studiato la composizione e la sintesi dei lipidi superficiali cutanei, le loro modificazioni in corso di patologie dermatologiche, l'effetto prodotto dalla esposizione ai raggi ultravioletti, la formazione di intermedi reattivi e la loro attività biologica sul sistema pigmentario ed immunitario.
Ha studiato l'interazione tra struttura chimica ed attività sensibilizzante di diversi allergeni. Negli ultimi anni le ricerche riguardano fondamentalmente il ruolo dei radicali liberi e della lipoperossidazione sulla induzione di danni cellulari e nello sviluppo di patologie dermatologiche attraverso l¹analisi dei processi responsabili della generazione di radicali liberi, la valutazione delle modificazioni del sistema antiossidante in vivo e la correlazione con il decorso di patologie dermatologiche.
Ha valutato il ruolo della produzione di specie radicaliche nella patogenesi della vitiligine e l¹efficacia terapeutica della somministrazione di antiossidanti in associazione con la fototerapia. Nell¹ambito dello studio dei fattori di rischio per melanoma ha esaminato le correlazioni tra livelli di antiossidanti sistemici, fototipo e sintesi di melanina, le modificazioni biochimiche e biologiche della cute dopo esposizione ai raggi ultravioletti ed il meccanismo protettivo degli antiossidanti utilizzando sistemi culturali, di cute ricostituita in vitro e analisi in vivo.
E¹ stato relatore su invito e chairman in numerosi congressi nazionali ed internazionali.
Richard A. Spritz, M.D.
Professor of Pediatrics & Director
of the Human Medical Genetics Program
University of Colorado Health Sciences Center
Denver, Colorado
Dr. Spritz received his B.S. degree from the University of Wisconsin-Madison, and his M.D. from the Pennsylvania State University, and served an internship and residency in Pediatrics at the University of Pennsylvania’s Children’s Hospital of Philadelphia. He subsequently undertook advanced clinical and research training in the Department of Human Genetics at the Yale University School of Medicine, where he was involved in some of the earliest work on recombinant DNA and human genes, including the first cloning of human genes and identification of the first human disease gene mutation. In 1981 Dr. Spritz joined the faculty of the Department of Medical Genetics at the University of Wisconsin-Madison, where he remained until he joined the CU faculty in 1998.
Over the past two decades, Dr. Spritz and his associates have published more than 155 scientific papers describing the identification of genes involved in causing a number of different human diseases, including hemoglobin disorders, albinism and other skin diseases, autoimmune diseases such as vitiligo and thyroid disease, and others.
Dr. Spritz has received a number of honors and awards, including the first annual research award from the Society for Pediatric Dermatology, the Research Achievement Award from the American Skin Association, and the Alumni Fellow medal from the Pennsylvania State University. Dr. Spritz has also served on a number of major national committees addressing a variety of topics, including being an early consultant to GenBank, the very first DNA sequence database. At CU, Dr. Spritz has Chaired the President’s Taskforce on Genomics and Biotechnology, charged with guiding development of the system-wide CU Genomics-Biotechnology Initiative.
Head, Dept of Dermatology & Ped Dermatology
National Reference Center for Rare Skin Diseases
Hôpital St André 1,
rue Jean Burguet F-33075 Bordeaux cedex
Francia
Born Nov 3, 1952
Married, 3 children
Current position: Professor of Dermatology, University Victor Segalen Bordeaux 2 and Head of the Department of Dermatology, Centre Hospitalier Universitaire de Bordeaux.
Address: Service de Dermatologie, Hôpital Saint André, 1 rue Jean Burguet, 33075 Bordeaux cx, France
Tel : + 33 556 79 47 06 Fax + 33 556 79 49 75 e-mail: alain.taieb@chu-bordeaux.fr
Education
Scientific degree in Biochemistry, 1975, Bordeaux I University
MD thesis 1982, Bordeaux II University. Dissertation on « Giant Pigmented Nevi and melanophakomatoses”
Board certified in Human Pathology, 1982
Board certified in Dermatology and Venereology, 1983
Hospital and University positions
Intern, Bordeaux University Hospitals: 1977-78 ; 1979-1982
Military junior physician, Hôpital Thermal des Armées, Amélie les Bains, 1978-1979
Chef de Clinique-Assistant des Hôpitaux (Dermatology, Bordeaux University Hospitals) : 1982-1984
Assistant Professor (Immunology and Dermatology, Bordeaux 2 University): 1984-1986.
Senior Research Fellow, Department of Dermatology, University of Michigan Medical School, 1986- 87
Assistant Professor (Immunology and Dermatology, Bordeaux 2 University) : 1987-1990
Associate Professor, Dermatovenereology, Bordeaux 2 University), 1990- 1999
Head of the Pediatric Dermatology Unit 1992-1998
Full Professor, Dermatovenereology, Bordeaux 2 University:1999-
Head of Department of Dermatology, Hôpital St André and Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants: 1999-
Head, National Reference Center for Rare Skin Diseases, 2005-
Learned Societies/ International duties
Serves or has served on the board of several national (Société Française de Dermatologie, Société de Recherche Dermatologique, past president) and international societies (ESPD, ESPCR, EAACI). Former president of the Société Française de Dermatologie Pédiatrique, and coordinator of the Inserm- Dermatological Learned Societies committee. Current associate editor, British Journal of Dermatology, Pigment Cell Research, and Pediatric Dermatology. Creation and management of the European Task Force on Atopic Dermatitis, 1990; Creation and management of the European Task Force on Vitiligo, 2003; Organiser of the annual course of Pediatric Dermatology, Arcachon since 1992; Organiser or co-organiser of several international meetings (European Soc Ped Dermatol, Bordeaux, 1990; European Soc Pigment Cell Res, Bordeaux, 1997, World Congress of Dermatology, Paris, 2002; International Symposium on Atopic Dermatitis, Arcachon 2005)
Publications, Clinical and Research Interests
Has authored more than 280 articles in peer-reviewed journals and more than 30 chapters in multiauthored books. Co-author of “History of Atopic Dermatitis” with Drs Wallach and Tilles, Masson, 2005. Major topics of interest: pediatric dermatology, atopic dermatitis, pigment cell disorders and ex-vivo study of the epidermal melanin unit (physiology and pathophysiology)
Research Laboratory: Laboratoire de Pathologie Moléculaire et Thérapie Génique, Inserm U876 (Director, H de Verneuil). Université V Segalen Bordeaux 2. 146, rue Léo Saignat, 33077 Bordeaux France Tel : + 33 556 57 57 14 32
Prof. Westerhof Wiete
Nederlands Institute for Pigmentary Disorders, IWO-gebouw, Academic Medical Center
Meibergdreef 35 NL
1105 AZ AMSTERDAM
Associazione Italiana Ricerca
e Informazione per la Vitiligine - ONLUS - via Borromeo, 29 - 20031 Cesano Maderno (MI) - p.i. 02999070135
